Weihrauch (H 15, Boswellia serrata) auch bei Meningeom wirksam?

[Johanna Teig]

Habe einen interessanten Beitrag gefunden:

Zur Erklärung: Es geht um einen Bestandteil der Weihrauchpflanze, der sich schon als Teilersatz für Cortison bei der Behandlung von Hirnödemen bewährt hat. Dem Wirkstoff werden in höherer Dosierung auch tumorhemmende Eigenschaften nachgesagt. Allerdings habe ich bisher nur vom Einsatz bei Glioblastomen und Astrozytomen gehört, vermutlich weil es bei Meningeomen seltener ein Ödem gibt.
Hier geht es aber zunächst nur um einen erfolgreichen Test an einer Zellkultur. Ausserdem steht leider nicht drin, um welche Meningeomzellen es sich handelte. Und die Vergleichswirkung auf gesunde Hirnzellen steht auch nicht drin.


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Planta Med 2002 May;68(5):397-401
 
Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells.

Park YS, Lee JH, Bondar J, Harwalkar JA, Safayhi H, Golubic M.

Cleveland Clinic Foundation, Department of Neurosurgery, Cleveland, OH 44195, USA.

Acetyl-11-keto-beta-boswellic acid (AKBA) is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate of the tree Boswellia serrata (frankincense). Because pentacyclic triterpenes have antiproliferative and cytotoxic effects against different tumor types, we investigated whether AKBA would act in a similar fashion on primary human meningioma cell cultures. Primary cell cultures were established from surgically removed meningioma specimens. The number of viable cells in the absence/presence of AKBA was determined by the non-radioactive cell proliferation assay. The activation status of the proliferative cell marker, extracellular signal-regulated kinase-1 and -2 (Erk-1 and Erk-2) was determined by immunoblotting with the antibody that recognizes the activated form of these proteins. Treatment of meningioma cells by AKBA revealed a potent cytotoxic activity with half-maximal inhibitory concentrations in the range of 2 - 8 microM. At low micromolar concentrations, AKBA rapidly and potently inhibited the phosphorylation of Erk-1/2 and impaired the motility of meningioma cells stimulated with platelet-derived growth factor BB. The cytotoxic action of AKBA on meningioma cells may be mediated, at least in part, by the inhibition of the Erk signal transduction pathway. Because of the central role the Erk pathway plays in signal transduction and tumorigenesis, further investigation into the potential clinical use for AKBA and related boswellic acids is warranted.

[Ulrich]

Hier ein weiterer Artikel über die Wirksamkeit von "modifiziertem H15" bei Meningeom.

Adv Exp Med Biol. 2002;507:387-93.

Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2.

Park YS, Lee JH, Harwalkar JA, Bondar J, Safayhi H, Golubic M.

Department of Neurosurgery, Cleveland Clinic Foundation, 9500 Euclid Avenue/NB2-120A, Cleveland, OH 44195, USA.

Acetyl-11-keto-beta-boswellic acid (AKBA) is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree Boswellia serrata (frankincense). AKBA has been recently identified as a novel, orally active, non-redox and non-competitive 5-lipoxygenase inhibitor that also inhibits topisomerase I and II in vitro. Because natural pentacyclic triterpenes have an antiproliferative effect against different tumor types, we investigated the effects of AKBA on the proliferation of 11 primary cell cultures established from human surgical specimens of meningiomas, common central nervous system tumors. Treatment of meningioma cells by AKBA revealed a potent cytotoxic activity with half-maximal inhibitory concentrations in the range of 2-8 microM. At similar, physiologically achievable concentrations, AKBA rapidly (within minutes) and potently inhibited the phosphorylation of extracellular signal-regulated kinase 1 and 2 (Erk-1 and Erk-2) in meningioma cells stimulated with platelet-derived growth factor BB. High expression level of 5-LO was detected in primary meningioma cells and surgical specimens by immunoblotting analysis, suggesting the possible role of 5-LO in meningioma tumorigenesis. Considering the critical importance of the Erk-1/2 signal transduction pathway not only in meningiomas but in other human neoplasms, the interruption of signaling through this evolutionarily conserved pathway might be one of the mechanisms by which AKBA induces suppression of proliferation and apoptosis of different tumor types.