Ich fand in der Literatur nur einen Artikel über hCG und Meningeom, der mir aussagekräftig erschien, aber hier ging es nur um die Wirkung von hCG auf Meningeom-Zellen im Reagenzglas.
Die Suche bei PubMed war: hCG meningioma, diese beiden Begriffe gab ich in die Suchmaske ein. Wer will, kann ja selbst noch weiter suchen.
PubMed erreicht man hier:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmedLink zu PubMed für diesen ArtikelJ Endocrinol. 1995 Apr;145(1):155-61.
Effect of glycoprotein and protein hormones on human meningioma cell proliferation in vitro.Boyle-Walsh E, Shenkin A, White MC, Fraser WD.
Department of Clinical Chemistry, Royal Liverpool University Hospital, UK.
Speculation that meningiomas are subject to female hormone influence is supported by their higher incidence in women and reports of exacerbation of symptoms during pregnancy and the luteal phase of the menstrual cycle. Previous reports have concentrated on the effects of the steroid hormones oestradiol and progesterone on meningioma proliferation. In this study we have investigated the roles of the glycoproteins LH, FSH and human chorionic gonadotrophin (hCG), and the protein hormones prolactin (PRL) and human placental lactogen (hPL) on the proliferation of human meningiomas in vitro. The three glycoproteins had an inhibitory effect on meningioma proliferation ranging from 5.0-50.0%, 10.0-63.0% and 2.4-34.0% at the highest concentrations of LH (25 mIU/ml), FSH (15 mIU/ml) and hCG (30 IU/ml) respectively. Cultures were also treated with PRL (100 and 200 ng/ml) and hPL (5 and 10 ng/ml) and the protein hormones had a stimulatory effect on cell proliferation of 12.0-55.5% and 11.4-73.6% when treated with 200 ng/ml PRL and 10 micrograms/ml hPL respectively. Our data suggest that increasing levels of the protein hormones PRL and hPL, falling levels of hCG and the absence of LH and FSH in the second and third trimesters of pregnancy may play a role in the acceleration of meningioma growth in these stages of pregnancy.