Habe einen interessanten Beitrag gefunden:
Zur Erklärung: Es geht um einen Bestandteil der Weihrauchpflanze, der sich schon als Teilersatz für Cortison bei der Behandlung von Hirnödemen bewährt hat. Dem Wirkstoff werden in höherer Dosierung auch tumorhemmende Eigenschaften nachgesagt. Allerdings habe ich bisher nur vom Einsatz bei Glioblastomen und Astrozytomen gehört, vermutlich weil es bei Meningeomen seltener ein Ödem gibt.
Hier geht es aber zunächst nur um einen erfolgreichen Test an einer Zellkultur. Ausserdem steht leider nicht drin, um welche Meningeomzellen es sich handelte. Und die Vergleichswirkung auf gesunde Hirnzellen steht auch nicht drin.
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Planta Med 2002 May;68(5):397-401
Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells.
Park YS, Lee JH, Bondar J, Harwalkar JA, Safayhi H, Golubic M.
Cleveland Clinic Foundation, Department of Neurosurgery, Cleveland, OH 44195, USA.
Acetyl-11-keto-beta-boswellic acid (AKBA) is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate of the tree Boswellia serrata (frankincense). Because pentacyclic triterpenes have antiproliferative and cytotoxic effects against different tumor types, we investigated whether AKBA would act in a similar fashion on primary human meningioma cell cultures. Primary cell cultures were established from surgically removed meningioma specimens. The number of viable cells in the absence/presence of AKBA was determined by the non-radioactive cell proliferation assay. The activation status of the proliferative cell marker, extracellular signal-regulated kinase-1 and -2 (Erk-1 and Erk-2) was determined by immunoblotting with the antibody that recognizes the activated form of these proteins. Treatment of meningioma cells by AKBA revealed a potent cytotoxic activity with half-maximal inhibitory concentrations in the range of 2 - 8 microM. At low micromolar concentrations, AKBA rapidly and potently inhibited the phosphorylation of Erk-1/2 and impaired the motility of meningioma cells stimulated with platelet-derived growth factor BB. The cytotoxic action of AKBA on meningioma cells may be mediated, at least in part, by the inhibition of the Erk signal transduction pathway. Because of the central role the Erk pathway plays in signal transduction and tumorigenesis, further investigation into the potential clinical use for AKBA and related boswellic acids is warranted.